Reduction of 2-Carboxy-4′-dimethylaminoazobenzene byBacillusDiaphorase
نویسندگان
چکیده
منابع مشابه
The metabolism of 4-dimethylaminoazobenzene by rat liver homogenates.
The intact rat metabolizes the hepatic carcinogen 4-dimethylaminoaeobenzene in several ways. Small amounts of the ingested dye and two demethylated derivatives, 4-monomethylaminoazobenzene and 4-aminoazobenzene, have been found in the liver and excreta (1). The latter two dyes and an unidentified aminoazo dye also occur in the liver firmly combined with protein; these bound dyes appear to be in...
متن کاملInability of 4-Dimethylaminoazobenzene To Act as a Major
In the rat and other species “labile― methyl groups are essential to normal metabolism (5). These are methyl groups which are capable of be ing transferred in toto from one compound to an other by specific enzymes and enzyme cofactors. In the rat the major source of such groups is the diet, which may contain them in the form of such compounds as i@-methionine, choline, betaine, and possibly...
متن کاملEffects of 4-dimethylaminoazobenzene on Hepatic Microsomal Phospholipids.
portion, consisting of fragments of the endoplasmic reticu lum, contain a higher proportion of phospholipids than any of the other cell fractions (6). In addition to phos pholipids, the microsomes are high in RNA, are the pri mary sites of protein synthesis within the cell, and may be more significantly affected by carcinogenic agents than the other cell components. Arcos and Arcos (1) observed...
متن کاملStructural and mechanistic studies on Klebsiella pneumoniae 2-Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase.
The stereospecific oxidative degradation of uric acid to (S)-allantoin was recently shown to proceed via three enzymatic steps. The final conversion is a decarboxylation of the unstable intermediate 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) and is catalyzed by OHCU decarboxylase. Here we present the structures of Klebsiella pneumoniae OHCU decarboxylase in unliganded form and with bo...
متن کاملHistochemical studies on rat liver proteins during 4-dimethylaminoazobenzene carcinogenesis.
Areas of preneoplastic livers characterized by intense RNA staining apparently represent the sites of neoplastic transformation. These hyperbasophilic foci, as well as the hepatomas, showed a marked decrease in the stain ing intensity of the cytoplasmic proteins in sections stained by the mercury-bromophenol blue method or the MillÃ3nreaction. Following extraction of the RNA, how ever, protein ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bulletin of the Chemical Society of Japan
سال: 1989
ISSN: 0009-2673,1348-0634
DOI: 10.1246/bcsj.62.1123